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KMID : 0438219770140020373
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Korea University Medical Journal
1977 Volume.14 No. 2 p.373 ~ p.381
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Ultratructural Localization of Vitamin A in Mouse Liver as revealed by Electron Microscope Radioautography
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Abstract
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Hypovitaminotic A mice were fed with tritiated vitamin A for seven days. One group of them (Group I) was sacrificed after tritiated vitamin A feeding. The other(Group Il) was fed with a diet rich in vitamin A for seven days more than Group I. Livers were taken out and processed by electron microscope radioautography.
The results were as follows:
1. Hepatic structures showing heavy labelings were nothing but fat storing cell.
2. Group difference of the labeling was merely recognized in the cell.
3. All the lipid droplets in the fat storing cell appeared to be heavily labeled with silver grains, and the labeling was heavier in Group II.
4. Labeling was hardly observed in the Kupffer cell.
5. Some labeling was found in the endothelial cell adjoining the fat storing cell.
6. Labeled lipid droplets were rarely found in the hepatocyte whose infoldings or vacuoles contained silver grains.
The results obtained from the present study reveal that vitamin A is not stored in the Kupffer cell but in the fat storing cell, and that the storage slowly proceeds after oral administration.
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